梁高林，男，江苏兴化人，国家杰出青年科学基金获得者。1993年本科毕业于南京大学强化部。2005年毕业于复旦大学药学院，获博士学位。1993年至2002年，江苏省原子医学研究所助理研究员。2005年9月至2008年1月香港科技大学化学系博士后，导师徐兵教授。2008年1月至2010年5月，美国斯坦福大学医学院博士后，导师饶江洪教授。主要从事分子与细胞显像的研究。在国际核心期刊上发表论文190余篇，H因子52。先后获得安徽省自然科学二等奖（排名第一）1项、国家二类新药证书1项、中国专利7项、世界专利1项，美国专利1项。获国务院政府特殊津贴（2020年）；入选2019年国家百千万人才工程，被授予“有突出贡献中青年专家”；获国家杰出青年科学基金（2017）、安徽省“百人计划”（2012）、安徽省杰出青年科学基金（2011）、教育部“新世纪优秀人才支持计划”（2010）等资助。主要研究方向为生物成像、生物医药、纳米探针（药物）自组装等。
代表性论文：
[1] Han Yin, Yue Hua, Songwei Feng, Yi Xu, Yue Ding, Sicong Liu, Dongsheng Chen, Furong Du, Gaolin Liang,* Wenjun Zhan,* and Yang Shen*. In Situ Nanofiber Formation Blocks AXL and GAS6 Binding to Suppress Ovarian Cancer Development. Adv. Mater. 2024, (DOI: 10.1002/adma.202308504).
[2] Xiaotong Cheng, Tiantian Xia, Xianbao Sun, Guowei Liang, Xiaoyang Liu, and Gaolin Liang*.Atg4B and Cathepsin B-Triggered in Situ Luciferin Formation for Precise Cancer Autophagy Bioluminescence Imaging. ACS Cent. Sci. 2023, 9(12), 2251-2256.
[3] Lingling Xu, Hang Gao, Wenjun Zhan,Yu Deng, Xiaoyang Liu, Qiaochu Jiang, Xianbao Sun, Jing-Juan Xu, andGaolin Liang*. Dual Aggregations of a Near-Infrared AIEgen for Enhanced Imaging of Alzheimer’s Disease. J. Am. Chem. Soc. 2023, 145(50), 27748-27756.
[4] Qiaochu Jiang, Wenjun Zhan, Xiaoyang Liu, Lin Bai, Manli Wang, Ying Xu, and Gaolin Liang*. Assembly drives regioselective azide-alkyne cycloaddition reaction. Nat. Commun. 2023, 14, 3935.
[5] Wenjun Zhan, Lingling Xu, Zhiyu Liu, Xiaoyang Liu, Ge Gao, Tiantian Xia, Xiaotong Cheng, Xianbao Sun, Fu-Gen Wu, Qian Yu, and Gaolin Liang*. Tandem Guest-Host-Receptor Recognitions Precisely Guide Ciprofloxacin to Eliminate Intracellular Staphylococcus aureus. Angew. Chem., Int. Ed. 2023, 62(32), e202306427.
[6] Xiaoyang Liu, Wenjun Zhan, Ge Gao, Qiaochu Jiang, Xinping Zhang, Hongbo Zhang, Xianbao Sun, Wei Han, Fu-Gen Wu, andGaolin Liang*. Apoptosis-Amplified Assembly of Porphyrin Nanofiber Enhances Photodynamic Therapy of Oral Tumor. J. Am. Chem. Soc. 2023, 145(14), 7918-7930.
[7] Lingling Xu, Nanhui Liu, Wenjun Zhan, Yu Deng, Zhaoxia Chen, Xiaoyang Liu, Ge Gao, Qian Chen, Zhuang Liu, andGaolin Liang*. Granzyme B Turns Nanoparticle Fluorescence “On” for Imaging Cytotoxic T Lymphocyte Activity in Vivo. ACS Nano 2022, 16(11), 19328-19334.
[8] Ge Gao, Xianbao Sun, Xiaoyang Liu, Runqun Tang, Manli Wang, Wenjun Zhan, Junnian Zheng,* and Gaolin Liang*. FAP-α-Instructed Coumarin Excimer Formation for High Contrast Fluorescence Imaging of Tumor. Nano Lett. 2022, 22(16), 6782-6786.
[9] Ge Gao, Yao-Wen Jiang, Wenjun Zhan, Xiaoyang Liu, Runqun Tang, Xianbao Sun, Yu Deng, Lingling Xu, and Gaolin Liang*. Trident Molecule with Nanobrush-Nanoparticle-Nanofiber Transition Property Spatially Suppresses Tumor Metastasis. J. Am. Chem. Soc. 2022, 144(26), 11897–11910.
[10]Chenchen Wang, Wei Du, Chengfan Wu, Shan Dan,Miao Sun,Tong Zhang,Bin Wang,Yue Yuan,* andGaolin Liang*. Cathespin B-Initiated Cypate Nanoparticle Formation for Tumor Photoacoustic Imaging. Angew. Chem. Int. Ed. 2022, 61, e202114766.
[11] Ge Gao, Xianbao Sun, Xiaoyang Liu, Yao-Wen Jiang, Runqun Tang, Yuxin Guo, Fu-Gen Wu,* and Gaolin Liang*.Intracellular Nanoparticle Formation and Hydroxychloroquine Release for Autophagy-Inhibited Mild-Temperature Photothermal Therapy of Tumor. Adv. Funct. Mater. 2021, 31(34), 2102832.
[12]Xiaotong Cheng, Hai-Dong Xu, Huan-Huan Ran,Gaolin Liang*, and Fugen Wu*.Glutathione-Depleting Nanomedicines for Synergistic Cancer Therapy. ACS Nano 2021, 15(5), 8039-8068.
[13] Ge Gao, Xianbao Sun*, and Gaolin Liang*.Nanoagent-Promoted Mild-Temperature Photothermal Therapy for Cancer Treatment. Adv. Funct. Mater. 2021, 31(25), 2100738.
[14] Zhonghua Shi,* Xiaoyan Li, Mengxing Wei, Peiyao Chen, Ting Zhang, Xiufeng Ling, Junqiang Zhang, Chun Zhao,* Fuqiang Wang,*and Gaolin Liang*.Receptor tyrosine kinases-instructed release of its inhibitor from hydrogel to delay ovarian aging.Biomaterials 2021, 269, 120536.
[15] Miaomiao Zhang, Yong Guan, Zheng Dang, Pinggen Zhang, Zhen Zheng, Liang Chen, Wen Kuang, Chenchen Wang, and Gaolin Liang*. Directly observing intracellular nanoparticle formation with nanocomputed tomography. Sci. Adv., 2020, 6(43), eaba3190.
[16] Ge Gao, Yao-Wen Jiang, Yuxin Guo, Hao-Ran Jia, Xiaotong Cheng, Yu Deng, Xin-Wang Yu, Ya-Xuan Zhu, Hao-Yue Guo, Wei Sun, Xiaoyang Liu, Jing Zhao, Shihe Yang, Zhi-Wu Yu, Fatima Maria Sierra Raya,Gaolin Liang,* and Fu-Gen Wu*. Enzyme-Mediated Tumor Starvation and Phototherapy Enhance Mild-Temperature Photothermal Therapy. Adv. Funct. Mater. 2020, 30, 1909391.
[17] Yanfang Wang, Wei Du, Tong Zhang, Yu Zhu, Yanhan Ni,Chenchen Wang, Fatima Maria Sierra Raya, Liwei Zou, Longsheng Wang,* and Gaolin Liang*. A Self-Evaluating Photothermal Therapeutic Nanoparticle. ACS Nano 2020, 14(8), 9585-9593.
[18]Wei Du, Yuanyuan Chong, Xiaomu Hu, Yanfang Wang, Yu Zhu, Jihua Chen, Xiaoxia Li, Qun Zhang, Guangfeng Wang,* Jun Jiang,* and Gaolin Liang*.Increasing Photothermal Efficacy by Simultaneous Intra- and Intermolecular Fluorescence Quenching. Adv. Funct. Mater. 2020, 30(5), 1908073.
[19] Zhanling Ding, Hongbin Sun, Shuchao Ge, Yuan Cai, Yue Yuan, Zijuan Hai, Tongxiang Tao, Jinming Hu,* Bing Hu,* Junfeng Wang,* and Gaolin Liang*. Furin-Controlled Fe3O4 Nanoparticle Aggregation and 19F Signal “Turn-On” for Precise MR Imaging of Tumor. Adv. Funct. Mater. 2019, 29(43), 1903860.
[20] Jiali Tan,* Mei Zhang, Zijuan Hai, Chengfan Wu, Jiong Lin, Wen Kuang, Hang Tang, Yulei Huang, Xiaodan Chen, and Gaolin Liang*. Sustained Release of Two Bioactive Factors from Supramolecular Hydrogel Promotes Periodontal Bone Regeneration. ACS Nano 2019, 13(5), 5616-5622.
[21] Zijuan Hai, Yanhan Ni, Dilizhatai Saimi, Hongyi Yang, Haiyang Tong, Kai Zhong,* and Gaolin Liang*.γ-Glutamyltranspeptidase-Triggered Intracellular Gadolinium Nanoparticle Formation Enhances the T2-Weighted MR Contrast of Tumor. Nano Lett. 2019, 19(4), 2428-2433.
[22]Peiyao Chen, Yinchu Ma, Zhen Zheng, Chengfan Wu, Yucai Wang,* and Gaolin Liang*. Facile syntheses of conjugated polymers for photothermal tumour therapy. Nat. Commun. 2019, 10, 1192.
[23]Chengfan Wu,Rui Zhang, Wei Du, Liang Cheng,* and Gaolin Liang*. Alkaline Phosphatase-Triggered Self-Assembly of Near-Infrared Nanoparticles for the Enhanced Photoacoustic Imaging of Tumors. Nano Lett. 2018, 18(12), 7749-7754.
[24]Wei Tang, Zhibin Zhao,Yuanyuan Chong, Chengfan Wu, Qingzhi Liu, Jingbo Yang, Rongbin Zhou, Zhe-Xiong Lian,* and Gaolin Liang*. Tandem Enzymatic Self-Assembly and Slow Release of Dexamethasone Enhances Its Antihepatic Fibrosis Effect. ACS Nano 2018, 12(10), 9966-9973.
[25]Jindao Wu, Zhen Zheng, Yuanyuan Chong, Xiangcheng Li, Liyong Pu, Qiyun Tang, Liu Yang, Xuehao Wang,* Fuqiang Wang,* and Gaolin Liang*. Immune Responsive Release of Tacrolimus to Overcome Organ Transplant Rejection. Adv. Mater. 2018, 30(45), 1805018.
[26]Zijuan Hai, Jindan Li, Jingjing Wu, Jiacheng Xuand Gaolin Liang*. Alkaline Phosphatase-TriggeredSimultaneous Hydrogelation and Chemiluminescence. J. Am. Chem. Soc.2017, 139(3), 1041-1044.
[27] Zhen Zheng, Peiyao Chen, Maolin Xie, Chengfan Wu, Yufeng Luo, Wentao Wang, Jun Jiang and Gaolin Liang*. Cell Environment-Differentiated Self-Assembly of Nanofibers. J. Am. Chem. Soc.2016, 138(35), 11128-11131.
[28] Yue Yuan, Fuqiang Wang, Wei Tang, Zhanling Ding, Lin Wang, Lili Liang, Zhen Zheng, Huafeng Zhang, and Gaolin Liang*. Intracellular Self-Assembly of Cyclic D-Luciferin Nanoparticles for Persistent Bioluminescence Imaging of Fatty Acid Amide Hydrolase. ACS Nano2016, 10(7), 7147-7153.
[29] Yue Yuan, Zhanling Ding, Junchao Qian, Jia Zhang, Jinyong Xu, Xuejiao Dong, Tao Han, Shuchao Ge, Yufeng Luo, Yuwei Wang, Kai Zhong,* and Gaolin Liang*.Casp3/7-Instructed Intracellular Aggregation of Fe3O4 Nanoparticles Enhances T2 MR Imaging of Tumor Apoptosis. Nano Lett. 2016, 16 (4), 2686-2691
[30] Yue Yuan, Lin Wang,Wei Du,Zhanling Ding,Jia Zhang,Tao Han, Linna An,Huafeng Zhang*, and Gaolin Liang*. Intracellular Self-Assembly of Taxol Nanoparticles for Overcoming Multi-Drug Resistance. Angew. Chem. Int. Ed. 2015, 54(33), 9700-9704.
[31] Yue Yuan, Shuchao Ge, Hongbin Sun, Xuejiao Dong, Hongxin Zhao, Linna An, Jia Zhang, Junfeng Wang, Bing Hu, Gaolin Liang*. Intracellular Self-Assembly and Disassembly of 19F Nanoparticles Confer Respective “Off” and “On” 19F NMR/MRI Signals for Legumain Activity Detection in Zebrafish. ACS Nano. 2015, 9(5), 5117-5124
[32] Shuang Liu, Anming Tang, Maolin Xie, Yundan Zhao, Jun Jiang, and Gaolin Liang*. Oligomeric Hydrogels Self-Assembled from Reduction-Controlled Condensation. Angew. Chem. Int. Ed. 2015, 54 (12), 3639-3642.
[33] Yue Yuan, Hongbin Sun, Shuchao Ge, Mengjing Wang, Hongxin Zhao, Lin Wang, Linna An, Jia Zhang, Huafeng Zhang, Bing Hu*, Junfeng Wang*, Gaolin Liang*. Controlled Intracellular Self-assembly and Disassembly of 19F Nanoparticles for MR Imaging of Caspase 3/7 in Zebrafish. ACS Nano. 2015, 9 (1), 761-768.
[34] Gaolin Liang, Hongjun Ren, and Jianghong Rao*. A biocompatible condensation reaction for controlled assembly of nanostructures in living cells. Nature Chemistry 2010, 2, 54-60.
邮箱：gliang@seu.edu.cn
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